What is hCG (human chorionic gonadotropin)?
hCG is a hormone that mimics luteinizing hormone (LH) and signals the testes to produce testosterone and sperm; it is often added to testosterone replacement therapy to preserve testicular function and fertility.
Human chorionic gonadotropin (hCG) is a protein hormone that acts similarly to luteinizing hormone (LH), a natural signaling molecule the pituitary gland normally releases to trigger testosterone production in the testes. When a man begins testosterone replacement therapy, the added exogenous testosterone typically suppresses the body's natural LH production, which can cause the testes to shrink and stop producing sperm on their own.
hCG is paired with testosterone therapy to counteract this effect. By mimicking LH, hCG stimulates the testes to continue manufacturing testosterone and maintaining sperm production during treatment. This helps preserve testicular volume and function, which is especially important for men who wish to remain fertile or avoid permanent atrophy of testicular tissue. Some hormone therapy clinics in Florida include hCG alongside testosterone as part of a combined replacement protocol, though the decision to use it depends on individual health goals and medical evaluation.
hCG is typically injected subcutaneously or intramuscularly and is measured in international units (IU). The specific dosing and frequency are individualized by a clinician based on baseline hormone levels, testicular health, and treatment objectives. Not every man on testosterone requires hCG, but many benefit from it to support overall hormonal balance and long-term testicular viability during hormone replacement.